Two years later after their first adventure, Tad Jones and Sara Lavrof have separate lives, he as a simple construction worker studying archaeology to graduate, and she as a renowned archaeologist and explorer.

After discovering the final clue of the existence of King Midas' necklace, Sara invites Tad to an exposition in Las Vegas, where he hopes that she accepts turning in his girlfriend. Just before to travel, Tad realizes that the mummy of Paititi has been exiled from the Inca city by help him and he appears on his home, forcing Tad to travel Las Vegas with his dog Jeff and the mummy.

But all hopes and dreams of Tad breaks when a millionaire named Jack Rackham kidnaps Sara to force her revealing the location of the three parts of Midas' necklace. Forming team with Tiffany (Sara's scholar), Mummy, the dog Jeff and Belzoni (Sara's pet, a grouch and intelligent bird who talks using show-bills), Tad Jones and his friends will travel around the world trying rescue Sara and defeat Rackham